Preheat the sauté function on your Instant Pot to medium-high heat. In a large bowl, toss pork pieces with kosher salt, black pepper, chili powder, garlic powder, onion powder, brown sugar, cumin, and oregano.
Add a small amount of neutral oil to the pot, then sear the pork in batches, turning until browned. Remove and set aside.
Pour half the beer into the pot and deglaze with a wooden spoon, scraping up all brown bits.
Add the pork back, followed by the remaining beer, orange juice, and garlic. Close the lid, set to high pressure, and cook for 40 minutes.
Allow a natural release for at least 20 minutes, then quick release any remaining pressure by turning the pressure valve..
For extra flavor and texture, shred the pork on a baking sheet, broil if desired, and sprinkle with flaky salt before serving.